Freie Stellen

Ausschreibung in englischer Sprache:

PhD position in “Microscopic Modeling of Protein-Drug Binding” (m/w/d)

The PhD project focusses on the application of molecular dynamics methods to characterize the binding of pharmacologically active molecules to proteins. Besides classical pharmaceutical agents, photoswitchable molecules will be investigated which can be activated by means of light. The goal is to provide a more detailed microscopic understanding of protein-drug interactions.

The project will be carried out in the newly established group “Development of Pharmacological Probes” led by Dr. Sebastian Thallmair at the Frankfurt Institute for Advanced Studies (FIAS) and Center for Multiscale Modeling in Life Sciences (CMMS).

In your research, you will apply high-performance computing to work on a topic connecting biophysics, medicinal chemistry, and biology. Your simulations will provide a more detailed picture of how pharmaceutical agents interact with their target proteins. You will be part of a highly interdisciplinary research institute and will interact with experimental and theoretical researchers.

Ideally, you have:

  • A Master’s degree in science (e.g. (theoretical) chemistry, (bio)physics, biology, or similar)
  • Basic knowledge in molecular dynamics
  • Excellent communication skills in English or
  • Previous experience in biomolecular simulation, programming, and quantum chemistry are not required, but are considered as a plus

We offer:

  • A highly inspiring working environment
  • Excellent research infrastructure and dedicated mentoring
  • A funded PhD position with competitive salary (65% , based on TV-H E13)
  • Excellent training and career development options (affiliation with the Goethe-University and the graduate school GRADE-iQbio)
  • The opportunity to live in Frankfurt am Main, a vibrant cosmopolitan city in close proximity to the Taunus mountain range

Applications may be submitted until February 28, 2021 but interviews will be scheduled as soon as possible. Ideally, the successful candidate will start in April 2021. The FIAS and the Thallmair group aim to offer a diverse and inclusive working environment and explicitly encourage applications of people belonging to underrepresented groups in science.

Apply now!

Required documents:

  • Motivation letter describing your research interests, your motivation to perform a PhD in the field and to join the lab
  • Detailed curriculum vitae including academic qualifications, research experience, skills, and possibly a publication list
  • Detailed transcripts  of records of your Bachelor’s and  Master’s programs 
  • Name and contact information of 1-2 references 

If you have any further questions, please do not hesitate to contact Dr. Sebastian Thallmair

Please upload all documents as a single pdf file using our application platform:

apply here!