Veranstaltungsort: Frankfurt Institute for Advanced Studies, Ruth-Moufang-Str. 1, 60438 Frankfurt am Main, Lecture Hall
Am 17.11.2022 hält Dr. Antonio Scialdone vom Helmholtz Zentrum München einen Vortrag zum Thema "Embryonic development".
Making heads or tails of mouse embryonic development using single-cell transcriptomics and physical modelling
Embryonic development is arguably the most spectacular manifestation of the cells' ability to self-organize in spatial patterns while changing their identity to generate different organs. However, how cells generate these complex and robust dynamics is still largely unknown.
In this talk, I will present our work aiming to address two key questions about mouse embryonic development: how do embryos decide where the head and the tail will form? How do they get rid of defective cells during their rapid growth? I will discuss how, to answer these questions, we analyze single-cell transcriptomic datasets and combine methods from machine learning and physics in close collaboration with experimental labs.