Venue: Frankfurt Institute for Advanced Studies, Ruth-Moufang-Str. 1, 60438 Frankfurt am Main, Lecture Hall

On 17.11.2022​, Dr. Antonio Scialdone of Helmholtz Centre Munich gives a talk on the topic "Embryonic development".

Title:

Making heads or tails of mouse embryonic development using single-cell transcriptomics and physical modelling

Abstract:

Embryonic development is arguably the most spectacular manifestation of the cells' ability to self-organize in spatial patterns while changing their identity to generate different organs. However, how cells generate these complex and robust dynamics is still largely unknown. 

In this talk, I will present our work aiming to address two key questions about mouse embryonic development: how do embryos decide where the head and the tail will form? How do they get rid of defective cells during their rapid growth? I will discuss how, to answer these questions, we analyze single-cell transcriptomic datasets and combine methods from machine learning and physics in close collaboration with experimental labs.

Scialdone Lab